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The effect of turmeric (Curcumin) supplementation on cytokine and inflammatory marker responses following 2 hours of endurance cycling

机译：续航2小时后，补充姜黄（姜黄素）对细胞因子和炎性标志物反应的影响

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Background: Endurance exercise induces IL-6 production from myocytes that is thought to impair intracellular defence mechanisms. Curcumin inhibits NF-κB and activator protein 1, responsible for cytokine transcription, in cell lines. The aim of this study was to investigate the effect of curcumin supplementation on the cytokine and stress responses following 2 h of cycling.Methods: Eleven male recreational athletes (35.5 ± 5.7 years; Wmax275 ± 6 W; 87.2 ± 10.3 kg) consuming a low carbohydrate diet of 2.3 ± 0.2 g/kg/day underwent three double blind trials with curcumin supplementation, placebo supplementation, and no supplementation (control) to observe the response of serum interleukins (IL-6, IL1-RA, IL-10), cortisol, c-reactive protein (CRP), and subjective assessment of training stress. Exercise was set at 95% lactate threshold (54 ± 7% Wmax) to ensure that all athletes completed the trial protocol.Results: The trial protocol elicted a rise in IL-6 and IL1-RA, but not IL-10. The supplementation regimen failed to produce statistically significant results when compared to placebo and control. IL-6 serum concentrations one hour following exercise were (Median (IQR): 2.0 (1.8-3.6) Curcumin; 4.8 (2.1-7.3) Placebo; 3.5 (1.9-7.7) Control). Differences between supplementation and placebo failed to reach statistical significance (p = 0.18) with the median test. Repeated measures ANOVA time-trial interaction was at p = 0.06 between curcumin supplementation and placebo. A positive correlation (p = 0.02) between absolute exercise intensity and 1 h post-exercise for IL-6 concentration was observed. Participants reported “better than usual” scores in the subjective assessment of psychological stress when supplementing with curcumin, indicating that they felt less stressed during training days (p = 0.04) compared to placebo even though there was no difference in RPE during any of the training days or trials.Conclusion: The limitations of the current regimen and trial involved a number of factors including sample size, mode of exercise, intensity of exercise, and dose of curcumin. Nevertheless these results provide insight for future studies with larger samples, and multiple curcumin dosages to investigate if different curcumin regimens can lead to statistically different interleukin levels when compared to a control and placebo.
机译：背景：耐力运动会诱导心肌细胞产生IL-6，这被认为会削弱细胞内防御机制。姜黄素抑制细胞系中负责细胞因子转录的NF-κB和激活蛋白1。这项研究的目的是研究骑行2小时后补充姜黄素对细胞因子和应激反应的影响方法：11名男性休闲运动员（35.5±5.7岁; Wmax275±6 W; 87.2±10.3 kg）对碳水化合物饮食为2.3±0.2 g / kg / day进行了3次双盲试验，分别补充姜黄素，安慰剂和不补充（对照），以观察血清白介素（IL-6，IL1-RA，IL-10）的反应，皮质醇，C反应蛋白（CRP）和训练压力的主观评估。将运动的乳酸阈值设置为95％（最大Wmax为54±7％），以确保所有运动员都完成了试验方案。结果：试验方案引起IL-6和IL1-RA升高，但IL-10却没有升高。与安慰剂和对照相比，补充方案未能产生统计学上显着的结果。运动后一小时的IL-6血清浓度为（中位数（IQR）：2.0（1.8-3.6）姜黄素; 4.8（2.1-7.3）安慰剂; 3.5（1.9-7.7）对照）。在中位数测试中，补充剂与安慰剂之间的差异未能达到统计学显着性（p = 0.18）。重复测量姜黄素补充剂和安慰剂之间的ANOVA时间试验相互作用为p = 0.06。观察到绝对运动强度与运动后1 h IL-6浓度呈正相关（p = 0.02）。参与者报告称，补充姜黄素后在心理压力的主观评估中得分“比平常好”，这表明与安慰剂相比，他们在训练日的压力较小（p = 0.04），尽管在任何训练中RPE均无差异结论：当前方案和试验的局限性涉及许多因素，包括样本量，运动方式，运动强度和姜黄素剂量。然而，这些结果为将来对更大的样本和多种姜黄素剂量进行研究提供了见识，以研究与对照和安慰剂相比不同的姜黄素方案是否可以导致统计学上不同的白介素水平。

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